Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a highly lethal cancer that contains cellular and functional heterogeneity.Previously, we enriched a subpopulation of highly tumorigenic head and neck cancer initiating cells (HN-CICs) from HNSCC.However, the molecular mechanisms by which to govern the characteristics of HN-CICs r